期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 112, 期 12, 页码 1776-1784出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200320530
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资金
- NIDDK NIH HHS [R01 DK055001, R01 DK062987, DK46282, DK55001, R01 DK046282, DK62987] Funding Source: Medline
Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.
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