期刊
NATURE CELL BIOLOGY
卷 5, 期 12, 页码 1111-1116出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1069
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Heterochromatin performs a central role in chromosome segregation and stability by promoting cohesion at centromeres(1,2). Establishment of both heterochromatin-mediated silencing and cohesion requires passage through S phase, although the mechanism is unknown(3,4). Here we demonstrate that Schizosaccharomyces pombe Hsk1 (CDC7), a conserved Dbf4-dependent protein kinase (DDK) that regulates replication initiation(5), interacts with and phosphorylates the heterochromatin protein 1 (HP1) equivalent Swi6 (ref. 6). Hsk1 and its regulatory subunit Dfp1 function downstream of Swi6 localization to promote heterochromatin function and cohesion specifically at centromeres. This role for Hsk1-Dfp1 is separable from its replication initiation activity, providing a temporal link between S phase and centromere cohesion that is mediated by heterochromatin.
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