期刊
CURRENT OPINION IN PHARMACOLOGY
卷 3, 期 6, 页码 635-641出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2003.07.006
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资金
- NCRR NIH HHS [M01RR2172] Funding Source: Medline
Dehydroepiandrosterone is the most abundant adrenal androgen and also functions as a neurosteroid. Serum concentrations decline with age and can serve as a prognostic factor in both critical illnesses and breast cancer progression. Evidence is accruing in support of dehydroepiandrosterone supplementation in adrenal insufficiency, hypopituitarism, osteoporosis, systemic lupus erythematosus, depression and schizophrenia. Research is ongoing at both the basic and the clinical level to elucidate mechanisms of action and establish efficacy and safety, as well as to expand new areas of potential application for this multi-faceted hormone.
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