期刊
TETRAHEDRON LETTERS
卷 44, 期 50, 页码 8947-8950出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2003.10.012
关键词
isocyanide; multicomponent reaction; thiazole; Passerini reaction
Diverse substituted 2-acyloxymethyl thiazoles can be assembled by a new multicomponent reaction (MCR) of methyl 3-(N,N-dimethylamino)-2-isocyanoacrylate, aldehydes and thiocarboxylic acid under Lewis acid catalysis. The reaction is performed under mild conditions and is compatible with a wide range of functionalized starting materials. 13 examples are given. (C) 2003 Elsevier Ltd. All rights reserved.
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