期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 100, 期 25, 页码 15154-15159出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2433165100
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资金
- NIAID NIH HHS [R01 AI40338, U01 AI047985, T32 AI007474, R01 AI040338, T32 AI07474, AI47985, AI52007, R01 AI052007, R01 AI058828] Funding Source: Medline
Human cells resist viral infections by a variety of mechanisms. Viruses must overcome host cell restrictions to successfully reproduce their genetic material. Here, we identify a host restriction to viral replication that acts at the stage of particle assembly. Viral protein U (Vpu) is an HIV-1 accessory protein that enhances particle assembly and release in most human cells, but not in simian cells. By using human-simian cell heterokaryons, we show that the inhibition of assembly in human cells is dominant. Vpu overcomes the block to assembly in human cells and in human-simian heterokaryons. The HIV-1 vpu gene may have evolved to counteract an assembly restriction that is present in human cells.
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