期刊
MACROMOLECULAR BIOSCIENCE
卷 3, 期 12, 页码 725-728出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200300012
关键词
biodegradation; hydrogel; proteinase K; temperature-responsive
Novel linear poly(NIPA-co-CL) copolymers have been synthesized by radical copolymerization of N-isopropylacrylamide (NIPA) and 2-methylene-1,3-dioxepane (MDO). The structure of copolymers was confirmed by H-1 NMR and IR spectroscopy. Cross-linked poly(NIPA-co-CL) hydrogels have also been prepared in toluene using N,N'-methylenebisacrylamide as cross-linking agent. The hydrogels thus obtained exhibit good temperature response and are biodegradable in the presence of proteinase K.
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