期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 90, 期 6, 页码 1079-1086出版社
WILEY-LISS
DOI: 10.1002/jcb.10714
关键词
gene therapy; NIS; biodistribution
There has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non-invasively the biodistribution, gene expression and replication of these viral vector systems. With the advent of molecular imaging technology, this deficiency is being rapidly rectified. A number of reporter genes have been used to monitor gene expression. In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes. (C) 2003 Wiley-Liss, Inc.
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