期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 13, 期 24, 页码 4451-4454出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2003.09.001
关键词
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To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed. (C) 2003 Elsevier Ltd. All rights reserved.
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