期刊
BRAIN RESEARCH BULLETIN
卷 62, 期 2, 页码 101-106出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2003.08.011
关键词
hydrogen peroxide (H2O2); apoptosis; cerebral vascular smooth muscle cells; brain injury; strokes
资金
- NIAAA NIH HHS [AA-08674] Funding Source: Medline
Recently, reactive oxygen species (ROS) have been suggested as important mediators of brain damage in a number of disease states, including traumatic brain injury, neurodegenerative diseases and strokes. Apoptosis has been suggested to play an important role in neurodegenerative diseases, traumatic brain injury and strokes. The aim of this study was to determine whether or not cerebral vascular smooth muscle cells (CVSMCs) undergo apoptosis following treatment with hydrogen peroxide (H2O2). Herein, we demonstrate, for the first time, that H2O2 can induce apoptosis in a concentration-dependent manner in primary cultured CVSMCs, as measured by several morphological and biochemical criteria. H2O2-induced apoptosis may be initiated by stimulating Ca2+-dependent endonuclease activity. The present new data suggest that apoptosis in cerebral VSMCs, induced by ROS, such as H2O2, could play important roles in nemodegenerative processes, traumatic brain injury and strokes. (C) 2003 Elsevier Inc. All rights reserved.
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