期刊
CLINICAL INFECTIOUS DISEASES
卷 37, 期 12, 页码 1711-1717出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/379776
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资金
- NCRR NIH HHS [K12 RR 17697] Funding Source: Medline
- NIAID NIH HHS [P30 AI054999, T32 AI 07474] Funding Source: Medline
- NIDDK NIH HHS [R01 DK-048831] Funding Source: Medline
Some diseases and environmental exposures, including those that are risk factors for atherosclerosis, are associated with increased oxidant stress. The objective of this cross- sectional, observational study was to determine whether oxidant stress is increased during human immunodeficiency virus type 1 ( HIV- 1) infection or its therapy. To quantify oxidant stress, plasma F-2 isoprostane ( F-2- IsoP) concentrations were determined by gas chromatography/ mass spectroscopy. A total of 120 subjects were enrolled during routine primary care visits. The median CD4(+) T cell count was 341 cells/ mm(3), the median HIV- 1 RNA level was 3.4 log(10) copies/ mL, and 74% of patients were receiving antiretroviral therapy. Plasma F-2- IsoP concentrations were 12 - 149 pg/ mL ( median, 31 pg/ mL). In univariate analysis, higher F-2- IsoP concentrations were associated with lower log(10) plasma HIV- 1 RNA levels (P = .009) and with efavirenz use (P = .02). Both factors remained associated with plasma F-2- IsoP concentrations in multivariate analysis. Oxidant stress associated with therapeutic control of viral replication may have important implications for long- term complications of antiretroviral therapy.
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