期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 420, 期 2, 页码 262-267出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2003.07.004
关键词
ischemia/reperfusion; cytochrome P450 monooxygenases; oxidative stress; eicosanoids
资金
- NHLBI NIH HHS [HL 60590, HL 61518] Funding Source: Medline
While attention has historically focused on mitochondria as the primary source of ROS in myocardial ischemia/reperfusion injury, recent evidence has implicated cytochrome P450 monooxygenases (CYPs) as a significant factor. CYPs represent a large family of enzymes that catalyze the oxidation of endogenous and exogenous compounds. They catalyze arachidonic acid oxidation to a variety of biologically active eicosanoids that regulate ion channels and protein kinases, with effects on vasomotor tone and cardiac inotropy. They also represent a significant source of reactive oxygen species that may target cellular homeostatic mechanisms and mitochondria. In this review, we will consider the contribution of cytochrome P450 enzymes to reperfusion injury and will speculate on whether the mechanism of injury is due to CYP-mediated ROS production or arachidonic acid metabolites. (C) 2003 Elsevier Inc. All rights reserved.
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