4.4 Article

Amyotrophic lateral sclerosis:: disease stage related changes of tau protein and S100 beta in cerebrospinal fluid and creatine kinase in serum

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NEUROSCIENCE LETTERS
卷 353, 期 1, 页码 57-60

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ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.neulet.2003.09.018

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amyotrophic lateral sclerosis; cerebrospinal fluid; protein tau; S100 beta; serum creatine kinase

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease leading to progressive cell death of upper and lower motor neurons and reactive astrogliosis. Two proteins which may be relevant in this respect (tau and S 100 beta) were studied in cerebrospinal fluid (CSF) next to routine parameters in 20 patients with sporadic ALS and 20 age-matched controls. Serum levels of creatine kinase (CK) were also determined to monitor the muscular involvement. S100 beta showed a significant decrease in CSF over the disease course (P = 0.024). CSF tau as well as serum CK were elevated in 70% of the ALS patients. While highest CSF tau levels were found rather in the early disease stages, serum CK showed a shift of the peak values to several months later. Elevation of the CSF/serum albumin quotient occurred in 20% of the cases most likely representing a non-specific finding in ALS. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

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