Lobar holoprosencephaly in a Miniature Schnauzer with hypodipsic hypernatremia

Holoprosencephaly is characterized by an absence or reduction in size of midline forebrain structures, incomplete separation of normally paired forebrain structures, and hydrocephalus. The condition may be genetic or a result of exposure to teratogens. It is possible that mild forms of holoprosencephaly play a role in some Miniature Schnauzers with hypodipsic hypernatremia; necropsy examination of additional affected dogs may confirm or refute this hypothesis.