期刊
BIOLOGICAL PSYCHIATRY
卷 54, 期 12, 页码 1382-1388出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(03)00571-7
关键词
PTSD; psychosis; comorbidity; corticotropin-releasing factor; HPA axis; somatostatin
Background: Recent studies have reported a high comorbidity between posttraumatic stress disorder (PTSD) and psychotic symptoms, and it has been hypothesized that PTSD with comorbid psychosis is a severe form of PTSD. Few studies have examined the neurobiology of PTSD with comorbid psychosis. If PTSD with secondary psychotic symptoms (PTSD-SP) is a severe form of PTSD, then it might be expected to show more extreme perturbations in the neuroendocrine patterns that characterize PTSD. Methods: Patients with PTSD with secondary psychotic symptoms (PTSD-SP), PTSD without psychosis, and healthy comparison subjects were compared for differences in cerebrospinal fluid concentrations of corticotropin-releasing factor (CRF) and somatotropin-release-inhibiting hormone (SRIF). Results: The PTSD-SP subjects had significantly higher mean levels of CRF than either the PTSD or control subjects (p < .01). The three groups showed similar SRIF levels. Conclusions: These data implicate abnormalities in the secretion of CRF with the production of secondary psychotic symptoms in PTSD. This finding supports the validity of PTSD-SP as a PTSD subtype and as a severe form of PTSD.
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