AMH signaling: from receptor to target gene

Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance (MIS), is a member of the transforming growth factor p (TGFbeta) superfamily and plays a crucial role during male sexual differentiation. Although the AMH type 11 receptor has been identified, the identity of the other signaling components has remained unknown. This review describes the identification of candidate AMH type I receptors and an AMH-target gene involved in Mullerian duct regression. (C) 2003 Elsevier Ireland Ltd. All rights reserved.