期刊
GENES & DEVELOPMENT
卷 17, 期 24, 页码 3087-3099出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1154103
关键词
skeletal myogenesis; cranial neural crest; head mesoderm; Wnt; BMP; Noggin; Gremlin; Frzb
资金
- NIDDK NIH HHS [P01 DK056246, P01 DK 56246] Funding Source: Medline
- NIGMS NIH HHS [R01 GM054879, GM 054879] Funding Source: Medline
Recent studies have postulated that distinct regulatory cascades control myogenic differentiation in the head and the trunk. However, although the tissues and signaling molecules that induce skeletal myogenesis in the trunk have been identified, the source of the signals that trigger skeletal muscle formation in the head remain obscure. Here we show that although myogenesis in the trunk paraxial mesoderm is induced by Wnt signals from the dorsal neural tube, myogenesis in the cranial paraxial mesoderm is blocked by these same signals. In addition, BMP family members that are expressed in both the dorsal neural tube and surface ectoderm are also potent inhibitors of myogenesis in the cranial paraxial mesoderm. We provide evidence suggesting that skeletal myogenesis in the head is induced by the BMP inhibitors, Noggin and Gremlin, and the Wnt inhibitor, Frzb. These molecules are secreted by both cranial neural crest cells and by other tissues surrounding the cranial muscle anlagen. Our findings demonstrate that head muscle formation is locally repressed by Writ and BMP signals and induced by antagonists of these signaling pathways secreted by adjacent tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据