期刊
FEBS LETTERS
卷 555, 期 3, 页码 591-596出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)01350-4
关键词
platelet-derived growth factor; vascular smooth muscle; DNA synthesis; phosphatidylinositol 3-kinase
The class 1(A) phosphatidylinositol 3-kinase enzymes consist of a number of heterodimeric complexes of regulatory and catalytic subunits and have been implicated in a number of cellular responses. While platelet-derived growth factor (PDGF)-induced chemotaxis of human vascular smooth muscle cells (HVSMC) is inhibited by both wortmannin and LY294002, DNA synthesis is only inhibited by LY294002. Serum-induced DNA synthesis however is inhibited by LY294002, wortmannin and rapamycin. Similarly PDGF-induced protein kinase B (PKB) activation is inhibited by LY294002 but not by wortmannin or rapamycin. In conclusion PDGF-induced DNA synthesis appears to occur through a phosphatidylinositol 3-kinase (PI3-K)-dependent, but wortmannin-insensitive, PKB/Akt pathway. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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