期刊
SYNTHESIS-STUTTGART
卷 -, 期 18, 页码 2890-2893出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2003-42479
关键词
amino acids; neutron capture therapy; boronic acid; synthesis; cyclobutanecarboxylic acid
A novel boronated aminocyclobutanecarboxylic acid was synthesized for potential use in neutron capture therapy. The synthesis involves the preparation of tosylate 5, which was then converted to an amino acid using Bucherer-Strecker methodology. The molecule was modeled after the unnatural amino acid, 1-aminocyclobutane-1-carboxylic acid, which has shown high uptake in brain tumors.
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