期刊
FEBS LETTERS
卷 555, 期 3, 页码 431-436出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)01295-X
关键词
interleukin-1; retinoic acid; ADAMTS; proteoglycan; arthritis
资金
- NIAMS NIH HHS [AR 40994] Funding Source: Medline
Aggrecanases are considered to play a key role in the destruction of articular cartilage during the progression of arthritis. Here we report that the N-terminal inhibitory domain of tissue inhibitor of metalloproteinases 3 (N-TIMP-3), but not TIMP-1 or TIMP-2, inhibits glycosaminoglycan release from bovine nasal and porcine articular cartilage explants stimulated with interleukin-la or retinoic acid in a dose-dependent manner. This inhibition is due to the blocking of aggrecanase activity induced by the catabolic factors. Little apoptosis of primary porcine chondrocytes is observed at an effective concentration of N-TIMP-3. These results suggest that TIMP-3 may be a candidate agent for use against cartilage degradation. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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