期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 278, 期 51, 页码 50961-50969出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M308028200
关键词
-
资金
- MRC [MC_U105663140] Funding Source: UKRI
- Medical Research Council [MC_U105663140] Funding Source: researchfish
- Medical Research Council [MC_U105663140] Funding Source: Medline
- NCI NIH HHS [CA95908, CA84302] Funding Source: Medline
- NIGMS NIH HHS [GM49294] Funding Source: Medline
Previous data from our laboratory suggested that replication of mammalian mitochondrial DNA initiates exclusively at or near to the formerly designated origin of heavy strand replication, O-H, and proceeds unidirectionally from that locus. New results obtained using two-dimensional agarose gel electrophoresis of replication intermediates demonstrate that replication of mitochondrial DNA initiates from multiple origins across a broad zone. After fork arrest near O-H, replication is restricted to one direction only. The initiation zone of bidirectional replication includes the genes for cytochrome b and NADH dehydrogenase subunits 5 and 6.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据