期刊
SCIENCE
卷 302, 期 5653, 页码 2134-2137出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1087667
关键词
-
资金
- NCRR NIH HHS [R24 RR012596] Funding Source: Medline
- NIH HHS [R24 OD010943] Funding Source: Medline
The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes. A conserved 55 - amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据