Synthesis of new peptidic glycoclusters derived from β-alanine

The synthesis of an asymmetric glycocluster 1 has been achieved by coupling of a sugar unit with the beta-alanine polypeptide, the principal chain, and combining a carbohydrate chain with the side chain causing it to branch from the N terminal. The synthesis of this side chain multivalent ligands is based on the scaffolding of some omega-amino acid (glycine, beta-alanine, and GABA) derivatives. This method facilitated the synthesis of the cluster, of which the length of each unit differs. (C) 2003 Elsevier Ltd. All rights reserved.