期刊
OPTICS EXPRESS
卷 11, 期 26, 页码 3598-3604出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.11.003598
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资金
- NCI NIH HHS [R01 CA103769, R01 CA103769-02] Funding Source: Medline
- NCRR NIH HHS [R01 RR019768, R01 RR019768-02] Funding Source: Medline
We demonstrate a high-speed spectral domain optical coherence tomography (SD-OCT) system capable of acquiring individual axial scans in 24.4 mus at a rate of 19,000 axial scans per second, using an InGaAs line scan camera and broadband light source centered at 1.31 mum. Sensitivity of >105 dB over a 2-mm depth range was obtained with a free-space axial resolution of 12-14 mum, in agreement with our signal-to-noise ratio predictions. Images of human tissue obtained in vivo with SD-OCT show similar penetration depths to those obtained with state-of-the-art time domain OCT despite the ten-fold higher image acquisition speed. These results demonstrate the potential of 1.3 mum SD-OCT for high-speed and high-sensitivity imaging in patients. (C) 2003 Optical Society of America.
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