期刊
VACCINE
卷 22, 期 3-4, 页码 511-519出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2003.07.020
关键词
new-borns; hepatitis B vaccine; Th1/Th2 cells
New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and naive adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults. (C) 2003 Elsevier Ltd. All rights reserved.
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