期刊
CHEMBIOCHEM
卷 5, 期 1, 页码 41-47出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200300721
关键词
activity-based profiling; enzymes; inhibitors; probes; proteomics
资金
- NCI NIH HHS [R01 CA087660-04, R01 CA087660, CA87660] Funding Source: Medline
The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profiling enable both the discovery and functional analysis of enzymes asociated with human disease.
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