期刊
TETRAHEDRON LETTERS
卷 45, 期 2, 页码 417-420出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2003.10.147
关键词
Ugi; Heck; multi-component reaction; solid-phase; scaffold
A new strategy employing an Ugi four-component reaction and a microwave-assisted intramolecular Heck cyclization in a sequential fashion to access an array of N-containing heterocycles is reported. The two-step sequence generated compounds of significant molecular complexity from trivial starting materials in an expedient fashion with excellent yields. The route was also amenable to solid-phase chemistry demonstrating potential for library generation. (C) 2003 Elsevier Ltd. All rights reserved.
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