期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 1, 页码 177-180出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2003.09.066
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dInhibition of the sodium hydrogen exchanger isoform-1 (NHE-1) has been shown to limit damage to the myocardium under ischemic conditions in animals. While most known NHE-1 inhibitors are acylguanidines, this report describes the design and synthesis of a series of heterocyclic inhibitors of NHE-1 including aminoimidazoles with undiminished in vitro activity and oral bioavailability. (C) 2003 Elsevier Ltd. All rights reserved.
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