期刊
CANCER LETTERS
卷 203, 期 1, 页码 25-33出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.canlet.2003.08.024
关键词
peroxisome proliferator-activated receptor; 9-cis retinoic acid receptor; PPAR gamma-coactivator-1; colorectal cancer
类别
Peroxisome proliferator-activated receptors (PPARs) alpha,beta/delta and gamma are fatty acid sensitive transcription factors that have been implicated in colorectal cancer. To better understand their role, we studied the expression levels of all PPAR-isoforms and transcriptional partners such as the retinoid X receptor alpha (RXRalpha) and PPARgamma-coactivator-1 (PGC-1) by means of real-time patients with colon cancer. While a heterogeneous pattern was observed for the expression level of the PPAR-isoforms alpha,beta/delta and gamma, the coactivator PGC-1 was significantly decreased in 15 of 17 tumors. Taken together our data suggest that the transcriptional activity of PPARgamma may not only be decreased by mutation but also by downregulation of the coactivator PGC-1 of PPARgamma. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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