期刊
SCIENCE
卷 303, 期 5655, 页码 229-232出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1090985
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资金
- NHGRI NIH HHS [HG02322] Funding Source: Medline
- NIAAA NIH HHS [P60 AA010760] Funding Source: Medline
- NIAMS NIH HHS [R01 AR044659-08, R01 AR044659, AR44659] Funding Source: Medline
The development of osteoporosis involves the interaction of multiple environmental and genetic factors. Through combined genetic and genomic approaches, we identified the lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice. Crossbreeding experiments with Alox15 knockout mice confirmed that 12/15-lipoxygenase plays a role in skeletal development. Pharmacologic inhibitors of this enzyme improved bone density and strength in two rodent models of osteoporosis. These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis.
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