期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 63, 期 47, 页码 10257-10262出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b04293
关键词
Syzygium jambos; phloroglucinol derivatives; structure identification; cytotoxic activity; antioxidant activity
资金
- National Natural Science Foundation of China [81202429, 81273390, 81473116]
- Fundamental Research Funds for the Central Universities [11615305]
- Natural Science Foundation of Guangdong Province [S2013020012864]
- 111 Project [B13038]
Seven new phloroglucinol derivatives (1-7) were isolated from the fruit tree Syzygium jambos together with four known triterpenoids (8-11) and two known flavones (12 and 13). According to the spectroscopic analyses (infrared, electrospray ionization mass spectrometry (ESIMS), high-resolution ESIMS, 1D and 2D nuclear magnetic resonance), the structures of compounds 1-7 were elucidated as jambone A (1), jambone B (2), jambone C (3), jambone D (4), jambone E (5), jambone F (6), and jambone G (7). All the isolates were determined for their cytotoxic activities on melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and compounds 10 and 11 showed potent activities. Moreover, compounds 1, 2, 4-7, 12, and 13 exhibited weak antioxidant activities under ferric-reducing antioxidant power and 2,2-diphenyl-1-picryhydrazyl radical-scavenging assays.
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