期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 468, 期 3, 页码 322-333出版社
WILEY
DOI: 10.1002/cne.10942
关键词
nicotinic receptors; immunohistochemistry; hippocampus; interneurons; astrocytes; mouse strains
资金
- NHLBI NIH HHS [P01 HL72903] Funding Source: Medline
- NIA NIH HHS [AG17517] Funding Source: Medline
- NIDA NIH HHS [DA015148] Funding Source: Medline
Neuronal nicotinic acetylcholine receptor (nAChR) expression and function are customized in different brain regions through assembling receptors from closely related but genetically distinct subunits. Immunohistochemical analysis of one of these subunits, nAChRbeta4, in the mouse brain suggests an extensive and potentially diverse role for this subunit in both excitatory and inhibitory neurotransmission. Prominent immunostaining included: 1) the medial habenula, efferents composing the fasciculus retroflexus, and the interpeduncular nucleus; 2) nuclei and ascending tracts of the auditory system inclusive of the medial geniculate; 3) the sensory cortex barrel field and cell bodies of the ventral thalamic nucleus; 4) olfactory-associated structures and the piriform cortex; and 5) sensory and motor trigeminal nuclei. In the hippocampus, nAChRbeta4 staining was limited to dendrites and soma of a subset of glutamic acid dehydrogenase-positive neurons. In C57BL/6 mice, but to a lesser extent in C3H/J, CBA/J, or CF1 mice, a subpopulation of astrocytes in the hippocampal CA1 region prominently expressed nAChRbeta4 (and nAChRalpha4). Collectively, these results suggest that the unique functional and pharmacological properties exerted by nAChRbeta4 on nAChR function could modify and specialize the development of strain-specific sensory and hippocampal-related characteristics of nicotine sensitivity including the development of tolerance. (C) 2003 Wiley-Liss, Inc.
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