期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 63, 期 30, 页码 6715-6722出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b00556
关键词
type 2 diabetes; oleuropein; hyperglycemia; impaired glucose tolerance; anxiety
资金
- Japan Society for the Promotion of Science (JSPS) [25860183]
- Grants-in-Aid for Scientific Research [25860183] Funding Source: KAKEN
Oleuropein, a phenolic compound found in abundance in olive leaves, has beneficial effects on various diseases'. However, it is unknown whether an oleuropein-rich diet is efficacious against type 2 diabetic phenotypes. In this study, we investigated the effects of the oleuropein-containing supplement OPIACE, whose oleuropein content exceeds 35% (w/w), on the diabetic phenotypes in type 2 diabetes model Tsumura Suzuki Obese Diabetes (TSOD) mouse. TSOD mice Were fed OPIACE at 4 weeks of age; i.e., before the TSOD mice exhibited diabetic phenotype. We revealed that OPIACE attenuated hyperglycemia and impaired glucose tolerance in TSOD mice over the long-term (from 10 to 24 weeks of age) but had no effect On obesity. Furthermore, we demonstrated that OPIACE mildly reduced oxidative stress in TSOD mice by 26.2% and attenuated anxiety-like behavioral abnormality in aged TSOD mice. The results suggest that oleuropein suppresses the progression of type 2 diabetes and diabetes-related behavioral abnormality over the long-term.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据