期刊
ANALYTICA CHIMICA ACTA
卷 501, 期 2, 页码 227-233出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2003.09.033
关键词
sildenafil citrate; oxidation mechanism; drug analysis; voltammetry
In aqueous solutions containing 30% (v/v) acetonitrile the unprotonated form of the piperazine ring of sildenafil (I) is oxidized on a glassy carbon electrode between pH 2 and 8. Whereas citrate anions under conditions used are not oxidized, the oxidation pattern of sulfonamides differs from that of sildenafil (I). On the other hand, the oxidation of I resembles that of the oxidation of piperazine ring in nefazodone (III) and trazodone (IV). A more positive peak of sildenafil corresponds to an adsorption-desorption process. Measurement of the peak current enables rapid determination of sildenafil (I) in pharmaceutical preparations with sufficient accuracy. (C) 2003 Elsevier B.V. All rights reserved.
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