Cyrmenins, novel antifungal peptides containing a nitrogen-linked β-methoxyacrylate pharmacophore:: Isolation and structural elucidation

The novel antifungal metabolites cyrmenin A, B-1, and B-2 (1-3) were isolated from Archangium gephyra and Cystobacter armeniaca strains (myxobacteria). The cyrmenins are modified N-acyldipeptide esters containing a didehydroalanine, a 3-O-methyl-didehydroserine and a (2E,4Z)-undecadienoic or -dodecadienoic acid residue. These compounds represent the first bacterial counterparts of strobilurins that are characterized by an alpha-substituted beta-methoxyacrylate pharmacophore. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).