期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 2, 页码 499-504出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2003.10.027
关键词
polar substitutions; benzenesulfonamide; 1,5-diarylpyrazoles; COX-2 inhibitors
Several chemical modifications in the N-1-benzenesulfonamide ring of celecoxib are presented. The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro. (C) 2003 Elsevier Ltd. All rights reserved.
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