Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors

In a previous paper, we reported that an imidazole derivative I exhibited a potent inhibitory activity of 20-HETE synthase (1; IC50 value of 5.7 nM), but this compound also exhibited little selectivity for cytochrome P450s (CYPs). We examined some derivatives of imidazole I which had an amino group on the side chain, and found that a dimethylaminohexyloxy derivative (3g ;IC50 value of 8.8 nM) showed potent and selective inhibitory activity. (C) 2003 Elsevier Ltd. All rights reserved.