期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 199, 期 2, 页码 221-229出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20031615
关键词
Wnt signaling; T cells; B cells; development; gene targeting
beta-catenin-mediated Writ signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is beta-catenin independent. In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
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