期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1024, 期 1-2, 页码 39-44出版社
ELSEVIER
DOI: 10.1016/j.chroma.2003.09.064
关键词
molecular imprinting; self-association; ligand binding; nuclear magnetic resonance spectroscopy; cooperative binding; nicotine
In the present study, the interactions of components in a (-)-nicotine molecular imprinting polymerization mixture have been studied by H-1 NMR spectroscopy. The dissociation constants for complexation of template by a functional monomer analogue, acetic acid, have been determined. Nicotine was shown to self-associate at concentrations comparable to those used in previous molecular imprinting studies (app K-diss = 0.082 M in CDCl3 at 298 K). The extent of self-association was enhanced by the presence of acetic acid. Previous studies on (-)-nicotine-imprinted methacrylic acid-ethylene dimethacrylate co-polymers suggested the involvement of recognition sites for template-template complexes. Collectively these results provide the first direct evidence for the presence of template-template complexes, and support the previously hypothesized basis for cooperative ligand recognition events in this polymer system. (C) 2003 Elsevier B.V. All rights reserved.
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