期刊
SCIENCE
卷 303, 期 5657, 页码 537-540出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1090042
关键词
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资金
- NIGMS NIH HHS [GM-065429-01A1] Funding Source: Medline
Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with mutational bias and is likely driven by natural selection to attain male germline function. However, the excess recruitment is consistent with a combination of both natural selection and mutational bias.
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