期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 4, 页码 1004-1009出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0307858100
关键词
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资金
- NIAID NIH HHS [AI-23764, P01 AI022295, R56 AI018785, AI-22295, R56 AI017134, R01 AI023764, R37 AI023764, R37 AI018785, R01 AI017134, AI-18785, AI-17134, R01 AI052225, R01 AI018785, AI-52225] Funding Source: Medline
The central zone of the supramolecular activation cluster (c-SMAC) is a zone of T cell receptor (TCR) enrichment that forms at a T cell/antigen-presenting cell (APC) junction in response to antigen stimulation. We demonstrate that there is a surprisingly complex relocalization process that brings PKCtheta and Bcl10, two intermediates in TCR activation of NF-KB, to the cytoplasmic face of the c-SMAC. TCR activation causes enrichment of PKCtheta at the c-SMAC, followed by Bcl10 relocalization to punctate cytoplasmic structures, often at sites distant from the c-SMAC. These Bcl10 structures then undergo further relocalization, becoming enriched at the c-SMAC. TCR activation of NF-B-K therefore involves the dynamic relocalization of multiple signaling intermediates, with distinct phases proximal to and distant from the c-SMAC.
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