期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 63, 期 31, 页码 6847-6865出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b02460
关键词
benzoylphenylurea; benzoylurea; chitin synthesis inhibitor; insect growth regulator; structure-activity relationship; toxicology
资金
- National Science Foundation of China [21132003, 21421062, 21202079, 21462028, 21364005]
- Startup Foundation for Outstanding Young Scientists of Inner Mongolia University [Z20080213, 115110]
- 111 Project of the Ministry of Education of China [B06005]
Benzoylurea chitin synthesis inhibitors are widely used in integrated pest management (IPM) and insecticide resistance management (IRM) programs due to their low toxicity to mammals and predatory insects. In the past decades, a large number of benzoylurea derivatives have been synthesized, and 15 benzoylurea chitin synthesis inhibitors have been commercialized. This review focuses on the history of commercial benzolyphenylureas (BPUs), synthetic methods, structure activity relationships (SAR), action mechanism research, environmental behaviors, and ecotoxicology. Furthermore, their disadvantages of high risk to aquatic invertebrates and crustaceans are pointed out. Finally, we propose that the para-substituents at anilide of benzoylphenylureas should be the functional groups, and bipartite model BPU analogues are discussed in an attempt to provide new insight for future development of BPUs.
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