期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 3, 页码 761-763出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm030858+
关键词
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Procedure of the synthesis is described for new platinum(IV) drug LA-12 [(OC-6-43)-bis-(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. The X-ray diffraction analysis shows that the structure is created by molecules with octahedral arrangement of ligands around a platinum atom and contains one H2O molecule that is not a part of the coordination sphere of platinum. This new drug is more reactive with glutathione than cisplatin and is lacking cross-resistance with cisplatin as proven on the panel of cancer cell lines.
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