期刊
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
卷 36, 期 1, 页码 5-15出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JOBB.0000019593.84933.e6
关键词
archaea; ABC transport; substrate-binding protein; signal peptide; Sulfolobus; Pyrococcus
In archaea, ATP-binding cassette (ABC) transporters play a crucial role in substrate uptake, export, and osmoregulation. Archaeal substrate-binding-protein-dependent ABC transporters are equipped with a very high affinity for their cognate substrates which provide these organisms with the ability to efficiently scavenge substrates from their environment even when present only at low concentration. Further adaptations to the archaeal way of life are especially found in the domain organization and anchoring of the substrate-binding proteins to the membrane. Examination of the signal peptides of binding proteins of 14 archaeal genomes showed clear differences between euryarchaeotes and crenarchaeotes. Furthermore, a profiling and comparison of ABC transporters in the three sequenced pyrococcal strains was performed.
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