期刊
HUMAN PATHOLOGY
卷 35, 期 2, 页码 176-183出版社
W B SAUNDERS CO
DOI: 10.1016/j.humpath.2003.10.008
关键词
breast cancer; Tie-2/Tek; CD105; CD31; prognosis; immunohistochemistry
类别
The immunocytochemical detection of Tie-2/Tek, CD105, and CD31 was assessed in a large series (n=905) of breast carcinomas on frozen sections. Results were correlated with patients' long-term outcome (median, 11.7 years) to define the respective prognostic significance of these markers. Univariate (Kaplan-Meier) analysis demonstrated that higher expression of CD31 (P=0.032), CD105 (P=0.001), and Tie-2/Tek (P=0.025) correlated with poorer survival. However, only greater CD105 expression could significantly (P=0.035) identify node-negative patients with poorer survival. Moreover, in multivariate analysis, CD105 and Tie-2/Tek, but not CD31, expression proved to be independent significant prognostic indicators. Marked expression of CD31 (P=0.024), CD105 (P=0.001), and Tie-2/Tek (P=0.01) also correlated with higher risk of metastases in node-negative patients. It is concluded that CD105 immunoexpression in breast carcinomas is an independent prognostic indicator in node-negative patients, better in terms of overall survival than Tie-2/Tek and CD31. Also, Tie-2/Tek expression proved more sensitive than CD31 expression in terms of prognostic significance. Compared with CD31, CD105 and Tie-2/Tek have more clinical relevance for patient monitoring and also can serve as targets for specific therapy, such as CD105 immunotoxins; or Tie-2/Tek pathway blockade, as recently suggested in experimental studies.
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