期刊
AGING CELL
卷 3, 期 1, 页码 3-6出版社
WILEY-BLACKWELL
DOI: 10.1046/j.1474-9728.2003.00073.x
关键词
adenine nucleotide translocase; calcium; cardio-lipin; membrane potential; oxidative stress; permeability transition
When mitochondria are subjected to oxidative stress and relatively high [Ca(2+)], they undergo a 'permeability transition' in which the inner membrane becomes freely permeable to low-molecular-weight solutes. This phenomenon reflects reversible deformation of the adenine nucleotide translocase, the loss of its native gating properties and the stabilization of the deformed state by cyclophilin-D. The permeability transition may be a factor in cell dysfunction associated with aging. This can manifest in a number of ways ranging, in the most severe, from impaired energy transduction and compromised viability to more subtle influences on the propagation of Ca(2+) signals. This article critically examines data relevant to this issue.
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