期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 63, 期 23, 页码 5640-5645出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b01441
关键词
Crypthecodinium cohnii; docosahexaenoic acid; microalgae; reactive oxygen species; sesamol
资金
- 985 Project of Peking University
- 863 Plan of Ministry of Science and Technology of China [2012AA023107]
- Public Science and Technology Research Funds Projects of Ocean [201505032]
- National Natural Science Foundation of China [31471717]
Sesamol is a strong, antioxidant phenolic compound found sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the Marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing, valuable insights into this alga for future biotechnological applications.
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