期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 77, 期 2, 页码 399-404出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2003.12.003
关键词
Valeriana; flavonoids; linarin; valerenic acid; CNS; sedation; sleep-enhancing properties; potentiation
We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of RN. The present paper reports the identification in V officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). These effects should be taken into account when considering the pharmacological actions of valeriana extracts. (C) 2003 Elsevier Inc. All rights reserved.
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