期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 24, 期 1, 页码 123-128出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:CEMN.0000012717.37839.07
关键词
neuroprotection; riluzole; glutamate uptake; amyotrophic lateral sclerosis; astrocyte culture
1. Riluzole is used for the treatment of amyotrophic lateral sclerosis and reported to have neuroprotective effects in animal models of Parkinson's disease, Huntington's disease, and brain ischemia. The neuroprotective action of riluzole has been attributed to its ability to inhibit glutamate release ( A. Doble, Neurology 47( 4): 233S-241S, 1996). 2. The effect of riluzole on L-[2,3-H-3] glutamate uptake was investigated in rat cortical astrocyte cultures. 3. Riluzole showed a biphasic concentration-dependent effect on basal glutamate uptake. At low concentrations ( 1 and 10 muM) riluzole significantly increased glutamate uptake, whereas from 100 1 M promoted a slight reduction. 4. Considering the large range of glutamate levels in the synaptic cleft, we studied the 1 muM riluzole effect on uptake of glutamate at different concentrations (1 - 1000 muM). Riluzole was more effective at low glutamate concentrations (10 muM), enhancing the basal glutamate uptake up to 42%. 5. The action of riluzole on astrocytic glutamate uptake could be an additional mechanism to its neuroprotective role, perhaps suggesting a modulatory action on glutamatergic system involving glutamate clearance from synaptic cleft.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据