期刊
INFECTION AND IMMUNITY
卷 72, 期 2, 页码 667-677出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.2.667-677.2004
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资金
- NIAID NIH HHS [AI2392] Funding Source: Medline
- NICHD NIH HHS [P01 HD018577, HD18577] Funding Source: Medline
- NIDCR NIH HHS [DE014219, R01 DE014219] Funding Source: Medline
Previous studies employing transmembrane assays suggested that Candida albicans and related species, as well as Saccharomyces cerevisiae, release chemoattractants for human polymorphonuclear leukocytes (PMNs). Because transmembrane assays do not definitively distinguish between chemokinesis and chemotaxis, single-cell chemotaxis assays were used to confirm these findings and test whether mating-type or white-opaque switching affects the release of attractant. Our results demonstrate that C albicans, C. dubliniensis, C. tropicalis, C. parapsilosis, and C. glabrata release bona fide chemoattractants for PMNs. S. cerevisiae, however, releases a chemokinetic factor but not a chemoattractant. Characterization of the C. albicans chemoattractant revealed that it is a peptide of approximately 1 kDa. Whereas the mating type of C. albicans did not affect the release of chemoattractant, switching did. White-phase cells released chemoattractant, but opaque-phase cells did not. Since the opaque phase of C. albicans represents the mating-competent phenotype, it may be that opaque-phase cells selectively suppress the release of chemoattractant to facilitate mating.
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