期刊
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
卷 231, 期 2-3, 页码 189-195出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2003.10.010
关键词
electrospray; internal energy; heated capillary; pressure effect
The internal energy distributions in a heated capillary nano-electrospray source have been determined using the survival yield method. At low capillary temperatures, the internal energy distribution is characterized by a low-energy tail, which can be attributed to a fraction of ions not fully desolvated in the heated capillary. This low-energy tais is shown to disappear when the source pressure is increased. This explains why increased source pressure is favorable in the case of highly hydrophilic compounds or non-covalent complexes in order to achieve sufficient desolvation without fragmentation. It is also shown that high temperature-low voltage are not equivalent to low temperature-high voltage source conditions. These observations are important for fundamental issues as well as for source-CID mass spectral library searching applications. (C) 2004 Elsevier B.V. All rights reserved.
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